Retinal Degenerations Associated With Systemic Diseases

Systemic diseases can have a significant impact on the health of our eyes and vision. In this blog article, we will be discussing retinal degenerations associated with systemic diseases(IRD). We will be providing ways, tips, reasons, solution, instruction, and tutorial on how to manage and prevent these retinal degenerations.

For years, I have dealt with patients with retinal degenerations associated with systemic diseases in my clinic. These systemic diseases consist of damage to genetic systems.

What is Retinal Degeneration?

Retinal Degenerations Associated With Systemic Diseases
What is Retinal Degeneration?

Retinal degeneration is the separation of the retinal nerve layer from the underlying pigment epithelium. It develops when fluid leaks between these two layers, mostly due to tears or holes in the retina. It is most common in patients with high myopia. The retinal layer is stretched as the anteroposterior diameter of the eye increases and the tension area on it begins to thin and deteriorate.

In some familial or degenerative diseases and infections, thinning and deterioration may occur around the retina. Meanwhile, for the same reasons, the vitreous gel begins to lose its homogeneity and deteriorate, the gel consistency changes and gradually separates from the retina. This separation is called vitreous detachment.

In the meantime, as the vitreous tissue, which shrinks and becomes opaque in places, passes through the visual axis in the eye, it is perceived by the person as a fly or a smoke screen flying in front of the eye.

Retinal Degenerations Associated With Systemic Diseases and Eye Health

There are a number of degenerative diseases of the retina that are associated with systemic diseases. These include retinitis pigmentosa, macular degeneration, and diabetic retinopathy. Each of these diseases can lead to vision loss and blindness.

University of Utah author Dr. Eileen Hwang‘s presentation titled Retinal Degenerations Associated with Systemic Disease in 2021, explained the hereditary and genetic methods of systemic diseases in a very comprehensive way.

What Systemic Diseases Cause Eye Problems?

Many systemic diseases have genetic findings and a general screening is important for early diagnosis. Many genetic symptoms overlap with other symptoms of disease states. Eye examination can aid in timely treatment and differential diagnosis, which can lead to preventable complications. Systemic diseases can show signs or symptoms in any part of the eye, including the outer surface, middle, and back of the eye.

  • Diabetes mellitus
  • Hypertension
  • Acromegaly
  • Multiple sclerosis

In fact, some retinal degenerations, such as age-related macular degeneration (AMD), can be inherited in a syndromic fashion. Other systemic disorders can also affect the eyes, including hypertension, diabetes mellitus, chronic kidney disease, and cerebrovascular disease. It is therefore important to recognize the symptoms of a systemic disease, and to take the necessary measures to prevent vision loss. In addition, if a patient has several ocular diseases, it is important to identify the underlying disease to determine the best course of treatment.

Methods Used For The Detection Of Hereditary Retinal Degenerations

A number of genetic tests can be used to identify inherited retinal degenerations. These tests are helpful in determining whether a patient has a disease that is inherited and whether it is a syndromic or non-syndromic disease. These tests can also be used to identify genes involved in a disease and to identify proteins coding for cuticle structural proteins.

The most common inherited retinal degeneration is Usher syndrome. This syndrome is characterized by loss of peripheral and central vision, attenuated visual fields, and congenital hearing loss. The disease is also associated with a genetic mutation in the rhodopsin gene. This mutation is associated with autosomal recessive inheritance and the condition can begin at a young age.

In conclusion, retinal degenerations associated with systemic diseases can have a significant impact on our vision. By being aware of the risk factors, symptoms, and treatment options, we can take steps to prevent or manage these degenerations. We hope that this blog article has provided you with some valuable information on how to do so.

Retinal Degenerations Associated With Systemic Diseases PDF

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